如何どうかする

1. 1to not be in one's right mind ; to lose one's mind ; to go crazy ; to be out of sorts Translated by Jiyomi
2. 2to be off ; to be wrong (as in something being the matter)
3. 3to deal with ; to manage ; to handle
4. 4to do ... or something (of the sort)

Other writings and readings

JMdict entry 2872416. Source and licence.